The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Abstract Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory colitis mouse models and inflammatory bowel diseases (IBD) patients...

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Autores principales: Cristian Doñas, Jocelyn Neira, Francisco Osorio-Barrios, Macarena Carrasco, Dominique Fernández, Carolina Prado, Alejandra Loyola, Rodrigo Pacheco, Mario Rosemblatt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/64dc632d8ccf474eadb8e5911839b251
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