UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

ABSTRACT Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by...

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Auteurs principaux: Liang Ma, Omar Salas, Kyle Bowler, Maor Bar-Peled, Amir Sharon
Format: article
Langue:EN
Publié: American Society for Microbiology 2017
Sujets:
Botrytis cinerea
UDP-4-keto-6-deoxyglucose
UDP-galactopyranose mutase
fungal cell wall
fungal nucleotide sugar metabolism
galactofuranose
Microbiology
QR1-502
Accès en ligne:https://doaj.org/article/64f60381e6044febbf061053744506f0
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https://doaj.org/article/64f60381e6044febbf061053744506f0

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