Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion

The mechanisms linking phenotypic heterogeneity to collective cancer invasion are unclear. Here the authors develop an image-guided genomic technique to select and amplify leader and follower cells fromin vitroinvading cell packs and find a cooperative symbiotic relationship between these two cell p...

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Autores principales:	J. Konen, E. Summerbell, B. Dwivedi, K. Galior, Y. Hou, L. Rusnak, A. Chen, J. Saltz, W. Zhou, L. H. Boise, P. Vertino, L. Cooper, K. Salaita, J. Kowalski, A. I. Marcus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64f60da8ca2d4bdfb02d02820683558f
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spelling	oai:doaj.org-article:64f60da8ca2d4bdfb02d02820683558f2021-12-02T17:06:05ZImage-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion10.1038/ncomms150782041-1723https://doaj.org/article/64f60da8ca2d4bdfb02d02820683558f2017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15078https://doaj.org/toc/2041-1723The mechanisms linking phenotypic heterogeneity to collective cancer invasion are unclear. Here the authors develop an image-guided genomic technique to select and amplify leader and follower cells fromin vitroinvading cell packs and find a cooperative symbiotic relationship between these two cell populations.J. KonenE. SummerbellB. DwivediK. GaliorY. HouL. RusnakA. ChenJ. SaltzW. ZhouL. H. BoiseP. VertinoL. CooperK. SalaitaJ. KowalskiA. I. MarcusNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. Konen E. Summerbell B. Dwivedi K. Galior Y. Hou L. Rusnak A. Chen J. Saltz W. Zhou L. H. Boise P. Vertino L. Cooper K. Salaita J. Kowalski A. I. Marcus Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
description	The mechanisms linking phenotypic heterogeneity to collective cancer invasion are unclear. Here the authors develop an image-guided genomic technique to select and amplify leader and follower cells fromin vitroinvading cell packs and find a cooperative symbiotic relationship between these two cell populations.
format	article
author	J. Konen E. Summerbell B. Dwivedi K. Galior Y. Hou L. Rusnak A. Chen J. Saltz W. Zhou L. H. Boise P. Vertino L. Cooper K. Salaita J. Kowalski A. I. Marcus
author_facet	J. Konen E. Summerbell B. Dwivedi K. Galior Y. Hou L. Rusnak A. Chen J. Saltz W. Zhou L. H. Boise P. Vertino L. Cooper K. Salaita J. Kowalski A. I. Marcus
author_sort	J. Konen
title	Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
title_short	Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
title_full	Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
title_fullStr	Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
title_full_unstemmed	Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
title_sort	image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/64f60da8ca2d4bdfb02d02820683558f
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Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion

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