Structural basis for the activation of acid ceramidase

Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight into its mechanism of action.

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Autores principales: Ahmad Gebai, Alexei Gorelik, Zixian Li, Katalin Illes, Bhushan Nagar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/64fac15bbf80415292cee1c052351f44
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