Structural basis for the activation of acid ceramidase

Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight into its mechanism of action.

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Autores principales:	Ahmad Gebai, Alexei Gorelik, Zixian Li, Katalin Illes, Bhushan Nagar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/64fac15bbf80415292cee1c052351f44
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spelling	oai:doaj.org-article:64fac15bbf80415292cee1c052351f442021-12-02T17:31:43ZStructural basis for the activation of acid ceramidase10.1038/s41467-018-03844-22041-1723https://doaj.org/article/64fac15bbf80415292cee1c052351f442018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03844-2https://doaj.org/toc/2041-1723Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight into its mechanism of action.Ahmad GebaiAlexei GorelikZixian LiKatalin IllesBhushan NagarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ahmad Gebai Alexei Gorelik Zixian Li Katalin Illes Bhushan Nagar Structural basis for the activation of acid ceramidase
description	Acid ceramidase (aCDase) hydrolyzes lysosomal membrane ceramide into sphingosine and its dysfunction leads to a variety of disease phenotypes. Here, the authors present structures of aCDase in its proenzyme and autocleaved forms, which provides insight into its mechanism of action.
format	article
author	Ahmad Gebai Alexei Gorelik Zixian Li Katalin Illes Bhushan Nagar
author_facet	Ahmad Gebai Alexei Gorelik Zixian Li Katalin Illes Bhushan Nagar
author_sort	Ahmad Gebai
title	Structural basis for the activation of acid ceramidase
title_short	Structural basis for the activation of acid ceramidase
title_full	Structural basis for the activation of acid ceramidase
title_fullStr	Structural basis for the activation of acid ceramidase
title_full_unstemmed	Structural basis for the activation of acid ceramidase
title_sort	structural basis for the activation of acid ceramidase
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/64fac15bbf80415292cee1c052351f44
work_keys_str_mv	AT ahmadgebai structuralbasisfortheactivationofacidceramidase AT alexeigorelik structuralbasisfortheactivationofacidceramidase AT zixianli structuralbasisfortheactivationofacidceramidase AT katalinilles structuralbasisfortheactivationofacidceramidase AT bhushannagar structuralbasisfortheactivationofacidceramidase
_version_	1718380496249946112

Structural basis for the activation of acid ceramidase

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