Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection <italic toggle="yes">In Vivo</italic> by a Mechanism Dependent on T Lymphocytes

Pharmacological Inhibition of Host Heme Oxygenase-1 Suppresses <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Infection <italic toggle="yes">In Vivo</italic> by a Mechanism Dependent on T Lymphocytes

ABSTRACT Heme oxygenase-1 (HO-1) is a stress response antioxidant enzyme which catalyzes the degradation of heme released during inflammation. HO-1 expression is upregulated in both experimental and human Mycobacterium tuberculosis infection, and in patients it is a biomarker of active disease. Whet...

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Main Authors: Diego L. Costa, Sivaranjani Namasivayam, Eduardo P. Amaral, Kriti Arora, Alex Chao, Lara R. Mittereder, Mamoudou Maiga, Helena I. Boshoff, Clifton E. Barry, Celia W. Goulding, Bruno B. Andrade, Alan Sher
Format: article
Language:EN
Published: American Society for Microbiology 2016
Subjects:
Microbiology
QR1-502
Online Access:https://doaj.org/article/64fdecdf902b4fefb96dcde0a01ffc15
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