Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet.

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Detalles Bibliográficos
Autores principales:	Flurin Item, Stephan Wueest, Vera Lemos, Sokrates Stein, Fabrizio C. Lucchini, Rémy Denzler, Muriel C. Fisser, Tenagne D. Challa, Eija Pirinen, Youngsoo Kim, Silvio Hemmi, Erich Gulbins, Atan Gross, Lorraine A. O’Reilly, Markus Stoffel, Johan Auwerx, Daniel Konrad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/651aa8c22bce4313bef6d51b35cf53ab
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spelling	oai:doaj.org-article:651aa8c22bce4313bef6d51b35cf53ab2021-12-02T14:40:34ZFas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function10.1038/s41467-017-00566-92041-1723https://doaj.org/article/651aa8c22bce4313bef6d51b35cf53ab2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00566-9https://doaj.org/toc/2041-1723Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet.Flurin ItemStephan WueestVera LemosSokrates SteinFabrizio C. LucchiniRémy DenzlerMuriel C. FisserTenagne D. ChallaEija PirinenYoungsoo KimSilvio HemmiErich GulbinsAtan GrossLorraine A. O’ReillyMarkus StoffelJohan AuwerxDaniel KonradNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Flurin Item Stephan Wueest Vera Lemos Sokrates Stein Fabrizio C. Lucchini Rémy Denzler Muriel C. Fisser Tenagne D. Challa Eija Pirinen Youngsoo Kim Silvio Hemmi Erich Gulbins Atan Gross Lorraine A. O’Reilly Markus Stoffel Johan Auwerx Daniel Konrad Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
description	Hepatic steatosis is a common disease closely associated with metabolic syndrome and insulin resistance. Here Item et al. show that Fas, a member of the TNF receptor superfamily, contributes to mitochondrial dysfunction, steatosis development, and insulin resistance under high fat diet.
format	article
author	Flurin Item Stephan Wueest Vera Lemos Sokrates Stein Fabrizio C. Lucchini Rémy Denzler Muriel C. Fisser Tenagne D. Challa Eija Pirinen Youngsoo Kim Silvio Hemmi Erich Gulbins Atan Gross Lorraine A. O’Reilly Markus Stoffel Johan Auwerx Daniel Konrad
author_facet	Flurin Item Stephan Wueest Vera Lemos Sokrates Stein Fabrizio C. Lucchini Rémy Denzler Muriel C. Fisser Tenagne D. Challa Eija Pirinen Youngsoo Kim Silvio Hemmi Erich Gulbins Atan Gross Lorraine A. O’Reilly Markus Stoffel Johan Auwerx Daniel Konrad
author_sort	Flurin Item
title	Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
title_short	Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
title_full	Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
title_fullStr	Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
title_full_unstemmed	Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
title_sort	fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/651aa8c22bce4313bef6d51b35cf53ab
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Fas cell surface death receptor controls hepatic lipid metabolism by regulating mitochondrial function

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