Self-organization of Plk4 regulates symmetry breaking in centriole duplication

During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation properties are regulated by autophosphorylation....

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Autores principales:	Shohei Yamamoto, Daiju Kitagawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/655ee060eb5d42cabcf5c08792cc7305
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spelling	oai:doaj.org-article:655ee060eb5d42cabcf5c08792cc73052021-12-02T15:35:35ZSelf-organization of Plk4 regulates symmetry breaking in centriole duplication10.1038/s41467-019-09847-x2041-1723https://doaj.org/article/655ee060eb5d42cabcf5c08792cc73052019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09847-xhttps://doaj.org/toc/2041-1723During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation properties are regulated by autophosphorylation.Shohei YamamotoDaiju KitagawaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shohei Yamamoto Daiju Kitagawa Self-organization of Plk4 regulates symmetry breaking in centriole duplication
description	During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation properties are regulated by autophosphorylation.
format	article
author	Shohei Yamamoto Daiju Kitagawa
author_facet	Shohei Yamamoto Daiju Kitagawa
author_sort	Shohei Yamamoto
title	Self-organization of Plk4 regulates symmetry breaking in centriole duplication
title_short	Self-organization of Plk4 regulates symmetry breaking in centriole duplication
title_full	Self-organization of Plk4 regulates symmetry breaking in centriole duplication
title_fullStr	Self-organization of Plk4 regulates symmetry breaking in centriole duplication
title_full_unstemmed	Self-organization of Plk4 regulates symmetry breaking in centriole duplication
title_sort	self-organization of plk4 regulates symmetry breaking in centriole duplication
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/655ee060eb5d42cabcf5c08792cc7305
work_keys_str_mv	AT shoheiyamamoto selforganizationofplk4regulatessymmetrybreakingincentrioleduplication AT daijukitagawa selforganizationofplk4regulatessymmetrybreakingincentrioleduplication
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Self-organization of Plk4 regulates symmetry breaking in centriole duplication

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