Modeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug design.

In this study we have calculated a 3D structure of apoptin and through modeling and docking approaches, we show its interaction with Bcr-Abl oncoprotein and its downstream signaling components, following which we confirm some of the newly-found interactions by biochemical methods. Bcr-Abl oncoprotei...

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Autores principales: Soumya Panigrahi, Jörg Stetefeld, Jaganmohan R Jangamreddy, Soma Mandal, Sanat K Mandal, Marek Los
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
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Acceso en línea:https://doaj.org/article/656e78c4119b43bda0cc0181d4f7153a
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