Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling

Magnesium implantation or supplementation ameliorates bone disorder in CFTR-mutant mice through an ATF4-dependent Wnt/β-catenin signaling

Magnesium metal and its alloys are being developed as effective orthopedic implants; however, the mechanisms underlying the actions of magnesium on bones remain unclear. Cystic fibrosis, the most common genetic disease in Caucasians caused by the mutation of CFTR, has shown bone disorder as a key cl...

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Main Authors: Jiankun Xu, Peijie Hu, Xiaotian Zhang, Junjiang Chen, Jiali Wang, Jieting Zhang, Ziyi Chen, Mei Kuen Yu, Yiu Wa Chung, Yan Wang, Xiaohu Zhang, Yifeng Zhang, Nianye Zheng, Hao Yao, Jiang Yue, Hsiao Chang Chan, Ling Qin, Ye Chun Ruan
Format: article
Language:EN
Published: KeAi Communications Co., Ltd. 2022
Subjects:
Magnesium implant
Cystic fibrosis-related bone disorder
ATF4
Wnt/β-catenin signaling
Materials of engineering and construction. Mechanics of materials
TA401-492
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/657116a1f8ca4ad3ba44165885c680ae
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https://doaj.org/article/657116a1f8ca4ad3ba44165885c680ae

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