Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.

Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the...

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Auteurs principaux: Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G Stevenson, J Pedro Simas
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2014
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Accès en ligne:https://doaj.org/article/657609098eef41d881ca0dbb012aa8a7
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