Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.

Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the...

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Autores principales:	Cristina Godinho-Silva, Sofia Marques, Diana Fontinha, Henrique Veiga-Fernandes, Philip G Stevenson, J Pedro Simas
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/657609098eef41d881ca0dbb012aa8a7
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spelling	oai:doaj.org-article:657609098eef41d881ca0dbb012aa8a72021-11-11T06:06:07ZDefining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.1553-73661553-737410.1371/journal.ppat.1004220https://doaj.org/article/657609098eef41d881ca0dbb012aa8a72014-06-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24967892/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition remain poorly defined. We used Murid Herpesvirus-4 (MuHV-4) to determine for a latently expressed viral epitope how MHC class-I binding and CTL functional avidity impact on host colonization. Tracking MuHV-4 recombinants that differed only in epitope presentation, we found little latitude for sub-optimal MHC class I binding before immune control failed. By contrast, control remained effective across a wide range of T cell functional avidities. Thus, we could define critical engagement thresholds for the in vivo immune control of virus-driven B cell proliferation.Cristina Godinho-SilvaSofia MarquesDiana FontinhaHenrique Veiga-FernandesPhilip G StevensonJ Pedro SimasPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 6, p e1004220 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Cristina Godinho-Silva Sofia Marques Diana Fontinha Henrique Veiga-Fernandes Philip G Stevenson J Pedro Simas Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
description	Persistent infections are subject to constant surveillance by CD8+ cytotoxic T cells (CTL). Their control should therefore depend on MHC class I-restricted epitope presentation. Many epitopes are described for γ-herpesviruses and form a basis for prospective immunotherapies and vaccines. However the quantitative requirements of in vivo immune control for epitope presentation and recognition remain poorly defined. We used Murid Herpesvirus-4 (MuHV-4) to determine for a latently expressed viral epitope how MHC class-I binding and CTL functional avidity impact on host colonization. Tracking MuHV-4 recombinants that differed only in epitope presentation, we found little latitude for sub-optimal MHC class I binding before immune control failed. By contrast, control remained effective across a wide range of T cell functional avidities. Thus, we could define critical engagement thresholds for the in vivo immune control of virus-driven B cell proliferation.
format	article
author	Cristina Godinho-Silva Sofia Marques Diana Fontinha Henrique Veiga-Fernandes Philip G Stevenson J Pedro Simas
author_facet	Cristina Godinho-Silva Sofia Marques Diana Fontinha Henrique Veiga-Fernandes Philip G Stevenson J Pedro Simas
author_sort	Cristina Godinho-Silva
title	Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
title_short	Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
title_full	Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
title_fullStr	Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
title_full_unstemmed	Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
title_sort	defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/657609098eef41d881ca0dbb012aa8a7
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Defining immune engagement thresholds for in vivo control of virus-driven lymphoproliferation.

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