Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity

Abstract Cellular heterogeneity in cancer represents a significant challenge. In order to develop effective and lasting therapies, it is essential to understand the source of this heterogeneity, and its role in tumor progression and therapy resistance. Here, we consider not only genetic and epigenet...

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Autores principales: Geoffrey M. Wahl, Benjamin T. Spike
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/657a1343dbc640d09e0f4e77d11190cc
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