Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity

Centriolar separation is thought to be crucial for centriole duplication, but the mechanism behind separation is poorly understood. Here, using micropatterning, the authors report that actomyosin forces influence the direction, distance, and time of centriole separation.

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Autores principales: Elisa Vitiello, Philippe Moreau, Vanessa Nunes, Amel Mettouchi, Helder Maiato, Jorge G. Ferreira, Irène Wang, Martial Balland
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/65e5c4e2368645a7ad2f6b3e546366e0
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