Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

Abstract Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network. Dysregulated mitochondrial dynamics ar...

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Main Authors: Yan Yu, Xiao-Dan Peng, Xiao-Jun Qian, Kai-Ming Zhang, Xiang Huang, Yu-Hong Chen, Yun-Tian Li, Gong-Kan Feng, Hai-Liang Zhang, Xue-Lian Xu, Shun Li, Xuan Li, Jia Mai, Zhi-Ling Li, Yun Huang, Dong Yang, Li-Huan Zhou, Zhuo-Yan Zhong, Jun-Dong Li, Rong Deng, Xiao-Feng Zhu
Format: article
Language:EN
Published: Nature Publishing Group 2021
Subjects:
Medicine
R
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/6601f6c66f7649e89ed624b91b63f812
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https://doaj.org/article/6601f6c66f7649e89ed624b91b63f812

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