Deletion of TLR4 reduces apoptosis and improves histology in a murine kidney transplant model

Abstract Acute kidney injury (AKI) after transplantation of human deceased donor kidneys is associated with upregulation of tubular toll like receptor 4 (TLR4), but whether TLR4 is required for AKI is unknown. We hypothesized that TLR4 knockout mice (TLR4KO) subjected to cold ischemia followed by ki...

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Autores principales: Swati Jain, Robert Plenter, Trevor Nydam, Ronald G. Gill, Alkesh Jani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/6651c1c55f124889a4a21bbb3cb3d3e9
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