Locus-Specific DNA Methylation Editing in Melanoma Cell Lines Using a CRISPR-Based System
DNA methylation is a key epigenetic modification implicated in the pathogenesis of numerous human diseases, including cancer development and metastasis. Gene promoter methylation changes are widely associated with transcriptional deregulation and disease progression. The advent of CRISPR-based techn...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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MDPI AG
2021
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| Accès en ligne: | https://doaj.org/article/66939659e9bd4b11a53e5d958255dd07 |
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