Targeted deletion of PAC1 receptors in retinal neurons enhances neuron loss and axonopathy in a model of multiple sclerosis and optic neuritis

Chronic inflammation drives synaptic loss in multiple sclerosis (MS) and is also commonly observed in other neurodegenerative diseases. Clinically approved treatments for MS provide symptomatic relief but fail to halt neurodegeneration and neurological decline. Studies in animal disease models have...

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Auteurs principaux: Christina Van, Michael C. Condro, Henly H. Ko, Anh Q. Hoang, Ruoyan Zhu, Kenny Lov, Patrick T. Ricaflanca, Anna L. Diep, Nhat N.M. Nguyen, Gerald S. Lipshutz, Allan MacKenzie-Graham, James A. Waschek
Format: article
Langue:EN
Publié: Elsevier 2021
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Accès en ligne:https://doaj.org/article/66958102771743ab9562848a5c15b89c
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