Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

Abstract DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF from patients with resolving arthritis, fully esta...

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Autores principales: Emmanuel Karouzakis, Karim Raza, Christoph Kolling, Christopher D. Buckley, Steffen Gay, Andrew Filer, Caroline Ospelt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/66ae989f317c47c48a1eb0beaea82838
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