The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein
Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimeri...
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| Auteurs principaux: | , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2020
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| Accès en ligne: | https://doaj.org/article/66f8acdf26af494eacd6829c2907021d |
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