The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein

Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimeri...

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Autores principales: Xinglei Liu, Lu Rao, Arne Gennerich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/66f8acdf26af494eacd6829c2907021d
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