The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein
Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimeri...
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Nature Portfolio
2020
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oai:doaj.org-article:66f8acdf26af494eacd6829c2907021d2021-12-02T13:24:15ZThe regulatory function of the AAA4 ATPase domain of cytoplasmic dynein10.1038/s41467-020-19477-32041-1723https://doaj.org/article/66f8acdf26af494eacd6829c2907021d2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19477-3https://doaj.org/toc/2041-1723Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimerizing tail of the motor to the AAA + ring.Xinglei LiuLu RaoArne GennerichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020) |
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DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
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Science Q Xinglei Liu Lu Rao Arne Gennerich The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| description |
Cytoplasmic dynein contains three active AAA + ATPases (AAA1, 3 and 4), but only the functions of AAA1 and 3 are known. Here, we perform single-molecule fluorescence and optical tweezers studies and show that AAA4 controls the priming stroke of the motion-generating linker, which connects the dimerizing tail of the motor to the AAA + ring. |
| format |
article |
| author |
Xinglei Liu Lu Rao Arne Gennerich |
| author_facet |
Xinglei Liu Lu Rao Arne Gennerich |
| author_sort |
Xinglei Liu |
| title |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| title_short |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| title_full |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| title_fullStr |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| title_full_unstemmed |
The regulatory function of the AAA4 ATPase domain of cytoplasmic dynein |
| title_sort |
regulatory function of the aaa4 atpase domain of cytoplasmic dynein |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/66f8acdf26af494eacd6829c2907021d |
| work_keys_str_mv |
AT xingleiliu theregulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein AT lurao theregulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein AT arnegennerich theregulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein AT xingleiliu regulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein AT lurao regulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein AT arnegennerich regulatoryfunctionoftheaaa4atpasedomainofcytoplasmicdynein |
| _version_ |
1718393097882173440 |