Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susc...
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Nature Portfolio
2019
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oai:doaj.org-article:676c4fca20864aaa9d086a45a85f61c32021-12-02T14:38:38ZJoint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis10.1038/s41467-019-09976-32041-1723https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c32019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09976-3https://doaj.org/toc/2041-1723Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility.John A. LeesBart FerwerdaPhilip H. C. KremerNicole E. WheelerMercedes Valls SerónNicholas J. CroucherRebecca A. GladstoneHester J. BootsmaNynke Y. RotsAlienke J. Wijmega-MonsuurElisabeth A. M. SandersKrzysztof TrzcińskiAnne L. WyllieAeilko H. ZwindermanLeonard H. van den BergWouter van RheenenJan H. VeldinkZitta B. HarboeLene F. LundboLisette C. P. G. M. de GrootNatasja M. van SchoorNathalie van der VeldeLars H. ÄngquistThorkild I. A. SørensenEllen A. NohrAlexander J. MentzerTara C. MillsJulian C. KnightMignon du PlessisSusan NzenzeJeffrey N. WeiserJulian ParkhillShabir MadhiThomas BenfieldAnne von GottbergArie van der EndeMatthijs C. BrouwerJeffrey C. BarrettStephen D. BentleyDiederik van de BeekNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| description |
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specific bacterial genetic variation associated with susceptibility. |
| format |
article |
| author |
John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek |
| author_facet |
John A. Lees Bart Ferwerda Philip H. C. Kremer Nicole E. Wheeler Mercedes Valls Serón Nicholas J. Croucher Rebecca A. Gladstone Hester J. Bootsma Nynke Y. Rots Alienke J. Wijmega-Monsuur Elisabeth A. M. Sanders Krzysztof Trzciński Anne L. Wyllie Aeilko H. Zwinderman Leonard H. van den Berg Wouter van Rheenen Jan H. Veldink Zitta B. Harboe Lene F. Lundbo Lisette C. P. G. M. de Groot Natasja M. van Schoor Nathalie van der Velde Lars H. Ängquist Thorkild I. A. Sørensen Ellen A. Nohr Alexander J. Mentzer Tara C. Mills Julian C. Knight Mignon du Plessis Susan Nzenze Jeffrey N. Weiser Julian Parkhill Shabir Madhi Thomas Benfield Anne von Gottberg Arie van der Ende Matthijs C. Brouwer Jeffrey C. Barrett Stephen D. Bentley Diederik van de Beek |
| author_sort |
John A. Lees |
| title |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_short |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_full |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_fullStr |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_full_unstemmed |
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| title_sort |
joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3 |
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