Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.

Memantine, an NMDA receptor antagonist used for treatment of Alzheimer's disease (AD), is known to block the nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). In the present study, we examined by wire myography if memantine inhibited α3β2-nAChRs located on cerebral...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Reggie Hui-Chao Lee, Ting-Yi Tseng, Celeste Yin-Chieh Wu, Po-Yi Chen, Mei-Fang Chen, Jon-Son Kuo, Tony Jer-Fu Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6785d2e913f94094bc80a409e369fd61
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6785d2e913f94094bc80a409e369fd61
record_format	dspace
spelling	oai:doaj.org-article:6785d2e913f94094bc80a409e369fd612021-11-18T07:13:20ZMemantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.1932-620310.1371/journal.pone.0040326https://doaj.org/article/6785d2e913f94094bc80a409e369fd612012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22792283/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Memantine, an NMDA receptor antagonist used for treatment of Alzheimer's disease (AD), is known to block the nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). In the present study, we examined by wire myography if memantine inhibited α3β2-nAChRs located on cerebral perivascular sympathetic nerve terminals originating in the superior cervical ganglion (SCG), thus, leading to inhibition of nicotine-induced nitrergic neurogenic dilation of isolated porcine basilar arteries. Memantine concentration-dependently blocked nicotine-induced neurogenic dilation of endothelium-denuded basilar arteries without affecting that induced by transmural nerve stimulation, sodium nitroprusside, or isoproterenol. Furthermore, memantine significantly inhibited nicotine-elicited inward currents in Xenopous oocytes expressing α3β2-, α7- or α4β2-nAChR, and nicotine-induced calcium influx in cultured rat SCG neurons. These results suggest that memantine is a non-specific antagonist for nAChR. By directly inhibiting α3β2-nAChRs located on the sympathetic nerve terminals, memantine blocks nicotine-induced neurogenic vasodilation of the porcine basilar arteries. This effect of memantine is expected to reduce the blood supply to the brain stem and possibly other brain regions, thus, decreasing its clinical efficacy in the treatment of Alzheimer's disease.Reggie Hui-Chao LeeTing-Yi TsengCeleste Yin-Chieh WuPo-Yi ChenMei-Fang ChenJon-Son KuoTony Jer-Fu LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 7, p e40326 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Reggie Hui-Chao Lee Ting-Yi Tseng Celeste Yin-Chieh Wu Po-Yi Chen Mei-Fang Chen Jon-Son Kuo Tony Jer-Fu Lee Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
description	Memantine, an NMDA receptor antagonist used for treatment of Alzheimer's disease (AD), is known to block the nicotinic acetylcholine receptors (nAChRs) in the central nervous system (CNS). In the present study, we examined by wire myography if memantine inhibited α3β2-nAChRs located on cerebral perivascular sympathetic nerve terminals originating in the superior cervical ganglion (SCG), thus, leading to inhibition of nicotine-induced nitrergic neurogenic dilation of isolated porcine basilar arteries. Memantine concentration-dependently blocked nicotine-induced neurogenic dilation of endothelium-denuded basilar arteries without affecting that induced by transmural nerve stimulation, sodium nitroprusside, or isoproterenol. Furthermore, memantine significantly inhibited nicotine-elicited inward currents in Xenopous oocytes expressing α3β2-, α7- or α4β2-nAChR, and nicotine-induced calcium influx in cultured rat SCG neurons. These results suggest that memantine is a non-specific antagonist for nAChR. By directly inhibiting α3β2-nAChRs located on the sympathetic nerve terminals, memantine blocks nicotine-induced neurogenic vasodilation of the porcine basilar arteries. This effect of memantine is expected to reduce the blood supply to the brain stem and possibly other brain regions, thus, decreasing its clinical efficacy in the treatment of Alzheimer's disease.
format	article
author	Reggie Hui-Chao Lee Ting-Yi Tseng Celeste Yin-Chieh Wu Po-Yi Chen Mei-Fang Chen Jon-Son Kuo Tony Jer-Fu Lee
author_facet	Reggie Hui-Chao Lee Ting-Yi Tseng Celeste Yin-Chieh Wu Po-Yi Chen Mei-Fang Chen Jon-Son Kuo Tony Jer-Fu Lee
author_sort	Reggie Hui-Chao Lee
title	Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
title_short	Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
title_full	Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
title_fullStr	Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
title_full_unstemmed	Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
title_sort	memantine inhibits α3β2-nachrs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/6785d2e913f94094bc80a409e369fd61
work_keys_str_mv	AT reggiehuichaolee memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT tingyitseng memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT celesteyinchiehwu memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT poyichen memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT meifangchen memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT jonsonkuo memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries AT tonyjerfulee memantineinhibitsa3b2nachrsmediatednitrergicneurogenicvasodilationinporcinebasilararteries
_version_	1718423792178429952

Memantine inhibits α3β2-nAChRs-mediated nitrergic neurogenic vasodilation in porcine basilar arteries.

Ejemplares similares