Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of Brassica rapa

Brassica rapa L. subsp. rapa (turnip greens), a traditionally consumed vegetable, is well-known due to its high content of glucosinolates, which are secondary metabolites with a positive biological activity for human health. Our hypothesis has been based on the...

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Autores principales:	Tania Merinas-Amo, María-Dolores Lozano-Baena, Sara Obregón-Cano, Ángeles Alonso-Moraga, Antonio de Haro-Bailón
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	turnip greens gluconapin progoitrin health safety toxicity Chemical technology TP1-1185
Acceso en línea:	https://doaj.org/article/6792b99a7fa4485cbe52f7459406bb35
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id	oai:doaj.org-article:6792b99a7fa4485cbe52f7459406bb35
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spelling	oai:doaj.org-article:6792b99a7fa4485cbe52f7459406bb352021-11-25T17:34:42ZRole of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>10.3390/foods101127202304-8158https://doaj.org/article/6792b99a7fa4485cbe52f7459406bb352021-11-01T00:00:00Zhttps://www.mdpi.com/2304-8158/10/11/2720https://doaj.org/toc/2304-8158<i>Brassica rapa</i> L. subsp. <i>rapa</i> (turnip greens), a traditionally consumed vegetable, is well-known due to its high content of glucosinolates, which are secondary metabolites with a positive biological activity for human health. Our hypothesis has been based on the relation between <i>B. rapa</i> glucosinolate content and its healthy properties, and our aim is to establish guidelines for safe <i>B. rapa</i> vegetable consumption. Three <i>B. rapa</i> cultivars (143N5, 143N7 and 163N7) have been characterized by HPLC analysis of purified extracts from leaf samples in order to determine their glucosinolate content and to relate this content to beneficial effects on DNA protection, lifespan extension and chemoprevention. In order to ascertain the heath properties in vitro and in vivo, toxicity activities were assayed in the <i>Drosophila melanogaster</i> and leukaemia cell models; genomic safety was also assessed in both models using genotoxicity, fragmentation and comet assay. The <i>Drosophila</i> model has also been used to study the antioxidative activity and the longevity induction. Our results showed a relationship between <i>B. rapa</i> glucosinolate content and its safety and benefices in its consumption. Gluconapin, the main <i>B. rapa</i> glucosinolate, was directly related with these wholesome effects. The relevant conclusion in the present research is focused on <i>B. rapa</i> cultivar 163N7 due to its high gluconapin content and low progoitrin content, which exert anti-cancer and DNA protection properties and could be recommended as being safe and healthy for human consumption.Tania Merinas-AmoMaría-Dolores Lozano-BaenaSara Obregón-CanoÁngeles Alonso-MoragaAntonio de Haro-BailónMDPI AGarticleturnip greensgluconapinprogoitrinhealthsafetytoxicityChemical technologyTP1-1185ENFoods, Vol 10, Iss 2720, p 2720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	turnip greens gluconapin progoitrin health safety toxicity Chemical technology TP1-1185
spellingShingle	turnip greens gluconapin progoitrin health safety toxicity Chemical technology TP1-1185 Tania Merinas-Amo María-Dolores Lozano-Baena Sara Obregón-Cano Ángeles Alonso-Moraga Antonio de Haro-Bailón Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
description	<i>Brassica rapa</i> L. subsp. <i>rapa</i> (turnip greens), a traditionally consumed vegetable, is well-known due to its high content of glucosinolates, which are secondary metabolites with a positive biological activity for human health. Our hypothesis has been based on the relation between <i>B. rapa</i> glucosinolate content and its healthy properties, and our aim is to establish guidelines for safe <i>B. rapa</i> vegetable consumption. Three <i>B. rapa</i> cultivars (143N5, 143N7 and 163N7) have been characterized by HPLC analysis of purified extracts from leaf samples in order to determine their glucosinolate content and to relate this content to beneficial effects on DNA protection, lifespan extension and chemoprevention. In order to ascertain the heath properties in vitro and in vivo, toxicity activities were assayed in the <i>Drosophila melanogaster</i> and leukaemia cell models; genomic safety was also assessed in both models using genotoxicity, fragmentation and comet assay. The <i>Drosophila</i> model has also been used to study the antioxidative activity and the longevity induction. Our results showed a relationship between <i>B. rapa</i> glucosinolate content and its safety and benefices in its consumption. Gluconapin, the main <i>B. rapa</i> glucosinolate, was directly related with these wholesome effects. The relevant conclusion in the present research is focused on <i>B. rapa</i> cultivar 163N7 due to its high gluconapin content and low progoitrin content, which exert anti-cancer and DNA protection properties and could be recommended as being safe and healthy for human consumption.
format	article
author	Tania Merinas-Amo María-Dolores Lozano-Baena Sara Obregón-Cano Ángeles Alonso-Moraga Antonio de Haro-Bailón
author_facet	Tania Merinas-Amo María-Dolores Lozano-Baena Sara Obregón-Cano Ángeles Alonso-Moraga Antonio de Haro-Bailón
author_sort	Tania Merinas-Amo
title	Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
title_short	Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
title_full	Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
title_fullStr	Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
title_full_unstemmed	Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>
title_sort	role of glucosinolates in the nutraceutical potential of selected cultivars of <i>brassica rapa</i>
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6792b99a7fa4485cbe52f7459406bb35
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Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of <i>Brassica rapa</i>

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