Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation of actomyosin followed by the P...

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Autores principales:	Meng Zhu, Chuen Yan Leung, Marta N. Shahbazi, Magdalena Zernicka-Goetz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67d03849c46c458394472948fa9b220e
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id	oai:doaj.org-article:67d03849c46c458394472948fa9b220e
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spelling	oai:doaj.org-article:67d03849c46c458394472948fa9b220e2021-12-02T14:42:45ZActomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo10.1038/s41467-017-00977-82041-1723https://doaj.org/article/67d03849c46c458394472948fa9b220e2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00977-8https://doaj.org/toc/2041-1723The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation of actomyosin followed by the Par complex.Meng ZhuChuen Yan LeungMarta N. ShahbaziMagdalena Zernicka-GoetzNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meng Zhu Chuen Yan Leung Marta N. Shahbazi Magdalena Zernicka-Goetz Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
description	The molecular trigger that establishes cell polarity in the mammalian embryo is unclear. Here, the authors show that de novo polarisation of the mouse embryo at the 8-cell stage is directed by Phospholipase C and Protein kinase C and occurs in two phases: polarisation of actomyosin followed by the Par complex.
format	article
author	Meng Zhu Chuen Yan Leung Marta N. Shahbazi Magdalena Zernicka-Goetz
author_facet	Meng Zhu Chuen Yan Leung Marta N. Shahbazi Magdalena Zernicka-Goetz
author_sort	Meng Zhu
title	Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
title_short	Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
title_full	Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
title_fullStr	Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
title_full_unstemmed	Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo
title_sort	actomyosin polarisation through plc-pkc triggers symmetry breaking of the mouse embryo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/67d03849c46c458394472948fa9b220e
work_keys_str_mv	AT mengzhu actomyosinpolarisationthroughplcpkctriggerssymmetrybreakingofthemouseembryo AT chuenyanleung actomyosinpolarisationthroughplcpkctriggerssymmetrybreakingofthemouseembryo AT martanshahbazi actomyosinpolarisationthroughplcpkctriggerssymmetrybreakingofthemouseembryo AT magdalenazernickagoetz actomyosinpolarisationthroughplcpkctriggerssymmetrybreakingofthemouseembryo
_version_	1718389573445222400

Actomyosin polarisation through PLC-PKC triggers symmetry breaking of the mouse embryo

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