Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the...

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Auteurs principaux:	Pam Speight, Michael Kofler, Katalin Szászi, András Kapus
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/67d278d9789b4beeabd324a5881a18b5
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id	oai:doaj.org-article:67d278d9789b4beeabd324a5881a18b5
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spelling	oai:doaj.org-article:67d278d9789b4beeabd324a5881a18b52021-12-02T14:38:36ZContext-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad310.1038/ncomms116422041-1723https://doaj.org/article/67d278d9789b4beeabd324a5881a18b52016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11642https://doaj.org/toc/2041-1723MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the smooth muscle actin promoter.Pam SpeightMichael KoflerKatalin SzásziAndrás KapusNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pam Speight Michael Kofler Katalin Szászi András Kapus Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
description	MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the smooth muscle actin promoter.
format	article
author	Pam Speight Michael Kofler Katalin Szászi András Kapus
author_facet	Pam Speight Michael Kofler Katalin Szászi András Kapus
author_sort	Pam Speight
title	Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
title_short	Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
title_full	Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
title_fullStr	Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
title_full_unstemmed	Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
title_sort	context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated mrtf and taz and tgfβ-regulated smad3
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/67d278d9789b4beeabd324a5881a18b5
work_keys_str_mv	AT pamspeight contextdependentswitchinchemomechanotransductionviamultilevelcrosstalkamongcytoskeletonregulatedmrtfandtazandtgfbregulatedsmad3 AT michaelkofler contextdependentswitchinchemomechanotransductionviamultilevelcrosstalkamongcytoskeletonregulatedmrtfandtazandtgfbregulatedsmad3 AT katalinszaszi contextdependentswitchinchemomechanotransductionviamultilevelcrosstalkamongcytoskeletonregulatedmrtfandtazandtgfbregulatedsmad3 AT andraskapus contextdependentswitchinchemomechanotransductionviamultilevelcrosstalkamongcytoskeletonregulatedmrtfandtazandtgfbregulatedsmad3
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Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

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