RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2

RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are in mammals. Fly PRC2 can drive formation of RNA-D...

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Auteurs principaux: Célia Alecki, Victoria Chiwara, Lionel A. Sanz, Daniel Grau, Osvaldo Arias Pérez, Elodie L. Boulier, Karim-Jean Armache, Frédéric Chédin, Nicole J. Francis
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/67fff55423e64e0eb9a287213bb9999c
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