RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2
RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are in mammals. Fly PRC2 can drive formation of RNA-D...
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Nature Portfolio
2020
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oai:doaj.org-article:67fff55423e64e0eb9a287213bb9999c2021-12-02T14:41:12ZRNA-DNA strand exchange by the Drosophila Polycomb complex PRC210.1038/s41467-020-15609-x2041-1723https://doaj.org/article/67fff55423e64e0eb9a287213bb9999c2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15609-xhttps://doaj.org/toc/2041-1723RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are in mammals. Fly PRC2 can drive formation of RNA-DNA hybrids in vitro.Célia AleckiVictoria ChiwaraLionel A. SanzDaniel GrauOsvaldo Arias PérezElodie L. BoulierKarim-Jean ArmacheFrédéric ChédinNicole J. FrancisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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DOAJ |
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EN |
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Science Q |
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Science Q Célia Alecki Victoria Chiwara Lionel A. Sanz Daniel Grau Osvaldo Arias Pérez Elodie L. Boulier Karim-Jean Armache Frédéric Chédin Nicole J. Francis RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| description |
RNA is implicated in the targeting and function of Polycomb Group (PcG) chromatin regulators. Here the authors show that R-loops, three-stranded nucleic acid structures formed by DNA and RNA, are formed at some PcG binding sites in flies, as they are in mammals. Fly PRC2 can drive formation of RNA-DNA hybrids in vitro. |
| format |
article |
| author |
Célia Alecki Victoria Chiwara Lionel A. Sanz Daniel Grau Osvaldo Arias Pérez Elodie L. Boulier Karim-Jean Armache Frédéric Chédin Nicole J. Francis |
| author_facet |
Célia Alecki Victoria Chiwara Lionel A. Sanz Daniel Grau Osvaldo Arias Pérez Elodie L. Boulier Karim-Jean Armache Frédéric Chédin Nicole J. Francis |
| author_sort |
Célia Alecki |
| title |
RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| title_short |
RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| title_full |
RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| title_fullStr |
RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| title_full_unstemmed |
RNA-DNA strand exchange by the Drosophila Polycomb complex PRC2 |
| title_sort |
rna-dna strand exchange by the drosophila polycomb complex prc2 |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/67fff55423e64e0eb9a287213bb9999c |
| work_keys_str_mv |
AT celiaalecki rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT victoriachiwara rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT lionelasanz rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT danielgrau rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT osvaldoariasperez rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT elodielboulier rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT karimjeanarmache rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT fredericchedin rnadnastrandexchangebythedrosophilapolycombcomplexprc2 AT nicolejfrancis rnadnastrandexchangebythedrosophilapolycombcomplexprc2 |
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1718389993226895360 |