Structural basis for the recognition of sulfur in phosphorothioated DNA

DNA phosphorothioation (PT-DNA) is a DNA backbone sulfur modification that is recognized by the type-IV restriction endonuclease ScoMcrA. Here the authors provide insights into sulfur recognition by solving the crystal structure of the PT-DNA bound sulfur-binding domain (SBD) from ScoMcrA and they f...

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Autores principales:	Guang Liu, Wencheng Fu, Zhenyi Zhang, Yao He, Hao Yu, Yuli Wang, Xiaolei Wang, Yi-Lei Zhao, Zixin Deng, Geng Wu, Xinyi He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68277cd60c3a42f695daacfee2069f52
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spelling	oai:doaj.org-article:68277cd60c3a42f695daacfee2069f522021-12-02T14:38:50ZStructural basis for the recognition of sulfur in phosphorothioated DNA10.1038/s41467-018-07093-12041-1723https://doaj.org/article/68277cd60c3a42f695daacfee2069f522018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07093-1https://doaj.org/toc/2041-1723DNA phosphorothioation (PT-DNA) is a DNA backbone sulfur modification that is recognized by the type-IV restriction endonuclease ScoMcrA. Here the authors provide insights into sulfur recognition by solving the crystal structure of the PT-DNA bound sulfur-binding domain (SBD) from ScoMcrA and they further show that SBD homologs are widely spread among prokaryotes.Guang LiuWencheng FuZhenyi ZhangYao HeHao YuYuli WangXiaolei WangYi-Lei ZhaoZixin DengGeng WuXinyi HeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Guang Liu Wencheng Fu Zhenyi Zhang Yao He Hao Yu Yuli Wang Xiaolei Wang Yi-Lei Zhao Zixin Deng Geng Wu Xinyi He Structural basis for the recognition of sulfur in phosphorothioated DNA
description	DNA phosphorothioation (PT-DNA) is a DNA backbone sulfur modification that is recognized by the type-IV restriction endonuclease ScoMcrA. Here the authors provide insights into sulfur recognition by solving the crystal structure of the PT-DNA bound sulfur-binding domain (SBD) from ScoMcrA and they further show that SBD homologs are widely spread among prokaryotes.
format	article
author	Guang Liu Wencheng Fu Zhenyi Zhang Yao He Hao Yu Yuli Wang Xiaolei Wang Yi-Lei Zhao Zixin Deng Geng Wu Xinyi He
author_facet	Guang Liu Wencheng Fu Zhenyi Zhang Yao He Hao Yu Yuli Wang Xiaolei Wang Yi-Lei Zhao Zixin Deng Geng Wu Xinyi He
author_sort	Guang Liu
title	Structural basis for the recognition of sulfur in phosphorothioated DNA
title_short	Structural basis for the recognition of sulfur in phosphorothioated DNA
title_full	Structural basis for the recognition of sulfur in phosphorothioated DNA
title_fullStr	Structural basis for the recognition of sulfur in phosphorothioated DNA
title_full_unstemmed	Structural basis for the recognition of sulfur in phosphorothioated DNA
title_sort	structural basis for the recognition of sulfur in phosphorothioated dna
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/68277cd60c3a42f695daacfee2069f52
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Structural basis for the recognition of sulfur in phosphorothioated DNA

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