Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.

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Autores principales:	Gang Zhang, Blanca Lopez Mendez, Garry G. Sedgwick, Jakob Nilsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/683703f88b40405d9999b5a8529ec761
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spelling	oai:doaj.org-article:683703f88b40405d9999b5a8529ec7612021-12-02T15:33:50ZTwo functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation10.1038/ncomms122562041-1723https://doaj.org/article/683703f88b40405d9999b5a8529ec7612016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12256https://doaj.org/toc/2041-1723The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.Gang ZhangBlanca Lopez MendezGarry G. SedgwickJakob NilssonNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
description	The BubR1/Bub3 complex regulates chromosome segregation to enable proper kinetochore-microtubule interactions and is also required for the spindle assembly checkpoint. Here the authors show that two distinct pools of BubR1/Bub3 exist at kinetochores to support both known functions of BubR1/Bub3.
format	article
author	Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson
author_facet	Gang Zhang Blanca Lopez Mendez Garry G. Sedgwick Jakob Nilsson
author_sort	Gang Zhang
title	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_short	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_full	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_fullStr	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_full_unstemmed	Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation
title_sort	two functionally distinct kinetochore pools of bubr1 ensure accurate chromosome segregation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/683703f88b40405d9999b5a8529ec761
work_keys_str_mv	AT gangzhang twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT blancalopezmendez twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT garrygsedgwick twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation AT jakobnilsson twofunctionallydistinctkinetochorepoolsofbubr1ensureaccuratechromosomesegregation
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Two functionally distinct kinetochore pools of BubR1 ensure accurate chromosome segregation

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