PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes

Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes, leads to the fatal disease progressive multifocal leukoencephalopathy (PML). There is no cure currently available for PML, so it is essentia...

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Autores principales: Michael P. Wilczek, Francesca J. Armstrong, Colleen L. Mayberry, Benjamin L. King, Melissa S. Maginnis
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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PML
Acceso en línea:https://doaj.org/article/6870eeaa06274f46a914f777622eabd3
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