Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other

Some kinesins exhibit off-axis power strokes but their impact on motility and force generation in microtubule overlaps has not been investigated so far. Here authors use a 3D in vitro motility assay and find that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes m...

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Autores principales:	Aniruddha Mitra, Laura Meißner, Rojapriyadharshini Gandhimathi, Roman Renger, Felix Ruhnow, Stefan Diez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/689b9c88ea3c45eeb1fc9488aee2a4b3
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spelling	oai:doaj.org-article:689b9c88ea3c45eeb1fc9488aee2a4b32021-12-02T16:49:45ZKinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other10.1038/s41467-020-16328-z2041-1723https://doaj.org/article/689b9c88ea3c45eeb1fc9488aee2a4b32020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16328-zhttps://doaj.org/toc/2041-1723Some kinesins exhibit off-axis power strokes but their impact on motility and force generation in microtubule overlaps has not been investigated so far. Here authors use a 3D in vitro motility assay and find that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes microtubule twisting and coiling.Aniruddha MitraLaura MeißnerRojapriyadharshini GandhimathiRoman RengerFelix RuhnowStefan DiezNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Aniruddha Mitra Laura Meißner Rojapriyadharshini Gandhimathi Roman Renger Felix Ruhnow Stefan Diez Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
description	Some kinesins exhibit off-axis power strokes but their impact on motility and force generation in microtubule overlaps has not been investigated so far. Here authors use a 3D in vitro motility assay and find that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes microtubule twisting and coiling.
format	article
author	Aniruddha Mitra Laura Meißner Rojapriyadharshini Gandhimathi Roman Renger Felix Ruhnow Stefan Diez
author_facet	Aniruddha Mitra Laura Meißner Rojapriyadharshini Gandhimathi Roman Renger Felix Ruhnow Stefan Diez
author_sort	Aniruddha Mitra
title	Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
title_short	Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
title_full	Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
title_fullStr	Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
title_full_unstemmed	Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
title_sort	kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/689b9c88ea3c45eeb1fc9488aee2a4b3
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Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other

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