A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of <named-content content-type="genus-species">Escherichia coli</named-content> to Cytotoxic and Mutagenic Purine Analogs

A Critical Role for the Putative NCS2 Nucleobase Permease YjcD in the Sensitivity of <named-content content-type="genus-species">Escherichia coli</named-content> to Cytotoxic and Mutagenic Purine Analogs

ABSTRACT The base analogs 6-N-hydroxylaminopurine (HAP) and 2-amino-HAP (AHAP) are potent mutagens in bacteria and eukaryotic organisms. Previously, we demonstrated that a defect in the Escherichia coli ycbX gene, encoding a molybdenum cofactor-dependent oxidoreductase, dramatically enhances sensiti...

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Autores principales: Stanislav G. Kozmin, Elena I. Stepchenkova, Stephen C. Chow, Roel M. Schaaper
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2013
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/68a2d8d2cfe84970ba00000775f93822
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