FMNL formins boost lamellipodial force generation

FMNL formins boost lamellipodial force generation

Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting...

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Autores principales: Frieda Kage, Moritz Winterhoff, Vanessa Dimchev, Jan Mueller, Tobias Thalheim, Anika Freise, Stefan Brühmann, Jana Kollasser, Jennifer Block, Georgi Dimchev, Matthias Geyer, Hans-Joachim Schnittler, Cord Brakebusch, Theresia E. B. Stradal, Marie-France Carlier, Michael Sixt, Josef Käs, Jan Faix, Klemens Rottner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/68b36f54d59e40399f6718c304c31181
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spelling oai:doaj.org-article:68b36f54d59e40399f6718c304c311812021-12-02T14:42:23ZFMNL formins boost lamellipodial force generation10.1038/ncomms148322041-1723https://doaj.org/article/68b36f54d59e40399f6718c304c311812017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14832https://doaj.org/toc/2041-1723Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.Frieda KageMoritz WinterhoffVanessa DimchevJan MuellerTobias ThalheimAnika FreiseStefan BrühmannJana KollasserJennifer BlockGeorgi DimchevMatthias GeyerHans-Joachim SchnittlerCord BrakebuschTheresia E. B. StradalMarie-France CarlierMichael SixtJosef KäsJan FaixKlemens RottnerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Frieda Kage
Moritz Winterhoff
Vanessa Dimchev
Jan Mueller
Tobias Thalheim
Anika Freise
Stefan Brühmann
Jana Kollasser
Jennifer Block
Georgi Dimchev
Matthias Geyer
Hans-Joachim Schnittler
Cord Brakebusch
Theresia E. B. Stradal
Marie-France Carlier
Michael Sixt
Josef Käs
Jan Faix
Klemens Rottner
FMNL formins boost lamellipodial force generation
description Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.
format article
author Frieda Kage
Moritz Winterhoff
Vanessa Dimchev
Jan Mueller
Tobias Thalheim
Anika Freise
Stefan Brühmann
Jana Kollasser
Jennifer Block
Georgi Dimchev
Matthias Geyer
Hans-Joachim Schnittler
Cord Brakebusch
Theresia E. B. Stradal
Marie-France Carlier
Michael Sixt
Josef Käs
Jan Faix
Klemens Rottner
author_facet Frieda Kage
Moritz Winterhoff
Vanessa Dimchev
Jan Mueller
Tobias Thalheim
Anika Freise
Stefan Brühmann
Jana Kollasser
Jennifer Block
Georgi Dimchev
Matthias Geyer
Hans-Joachim Schnittler
Cord Brakebusch
Theresia E. B. Stradal
Marie-France Carlier
Michael Sixt
Josef Käs
Jan Faix
Klemens Rottner
author_sort Frieda Kage
title FMNL formins boost lamellipodial force generation
title_short FMNL formins boost lamellipodial force generation
title_full FMNL formins boost lamellipodial force generation
title_fullStr FMNL formins boost lamellipodial force generation
title_full_unstemmed FMNL formins boost lamellipodial force generation
title_sort fmnl formins boost lamellipodial force generation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/68b36f54d59e40399f6718c304c31181
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