Rapid and deep-scale ubiquitylation profiling for biology and translational research

Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.

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Autores principales: Namrata D. Udeshi, Deepak C. Mani, Shankha Satpathy, Shaunt Fereshetian, Jessica A. Gasser, Tanya Svinkina, Meagan E. Olive, Benjamin L. Ebert, Philipp Mertins, Steven A. Carr
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/68ca13e669fe40e6b40606c8ff538f1d
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