Rapid and deep-scale ubiquitylation profiling for biology and translational research

Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.

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Autores principales:	Namrata D. Udeshi, Deepak C. Mani, Shankha Satpathy, Shaunt Fereshetian, Jessica A. Gasser, Tanya Svinkina, Meagan E. Olive, Benjamin L. Ebert, Philipp Mertins, Steven A. Carr
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68ca13e669fe40e6b40606c8ff538f1d
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spelling	oai:doaj.org-article:68ca13e669fe40e6b40606c8ff538f1d2021-12-02T17:31:55ZRapid and deep-scale ubiquitylation profiling for biology and translational research10.1038/s41467-019-14175-12041-1723https://doaj.org/article/68ca13e669fe40e6b40606c8ff538f1d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14175-1https://doaj.org/toc/2041-1723Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.Namrata D. UdeshiDeepak C. ManiShankha SatpathyShaunt FereshetianJessica A. GasserTanya SvinkinaMeagan E. OliveBenjamin L. EbertPhilipp MertinsSteven A. CarrNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Namrata D. Udeshi Deepak C. Mani Shankha Satpathy Shaunt Fereshetian Jessica A. Gasser Tanya Svinkina Meagan E. Olive Benjamin L. Ebert Philipp Mertins Steven A. Carr Rapid and deep-scale ubiquitylation profiling for biology and translational research
description	Comprehensive protein ubiquitylation profiling by mass spectrometry typically requires large sample amounts, limiting its applicability to tissue samples. Here, the authors present an optimized proteomics method that enables multiplexed ubiquitylome analysis of cells and tumor tissue samples.
format	article
author	Namrata D. Udeshi Deepak C. Mani Shankha Satpathy Shaunt Fereshetian Jessica A. Gasser Tanya Svinkina Meagan E. Olive Benjamin L. Ebert Philipp Mertins Steven A. Carr
author_facet	Namrata D. Udeshi Deepak C. Mani Shankha Satpathy Shaunt Fereshetian Jessica A. Gasser Tanya Svinkina Meagan E. Olive Benjamin L. Ebert Philipp Mertins Steven A. Carr
author_sort	Namrata D. Udeshi
title	Rapid and deep-scale ubiquitylation profiling for biology and translational research
title_short	Rapid and deep-scale ubiquitylation profiling for biology and translational research
title_full	Rapid and deep-scale ubiquitylation profiling for biology and translational research
title_fullStr	Rapid and deep-scale ubiquitylation profiling for biology and translational research
title_full_unstemmed	Rapid and deep-scale ubiquitylation profiling for biology and translational research
title_sort	rapid and deep-scale ubiquitylation profiling for biology and translational research
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/68ca13e669fe40e6b40606c8ff538f1d
work_keys_str_mv	AT namratadudeshi rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT deepakcmani rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT shankhasatpathy rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT shauntfereshetian rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT jessicaagasser rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT tanyasvinkina rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT meaganeolive rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT benjaminlebert rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT philippmertins rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch AT stevenacarr rapidanddeepscaleubiquitylationprofilingforbiologyandtranslationalresearch
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Rapid and deep-scale ubiquitylation profiling for biology and translational research

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