Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize

Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize

Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death du...

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Autores principales: Stephen R. Adams, Howard C. Yang, Elamprakash N. Savariar, Joe Aguilera, Jessica L. Crisp, Karra A. Jones, Michael A. Whitney, Scott M. Lippman, Ezra E. W. Cohen, Roger Y. Tsien, Sunil J. Advani
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/68ca94c8c46f45f584cf14bf29ee56ae
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https://doaj.org/article/68ca94c8c46f45f584cf14bf29ee56ae

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