Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize

Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death du...

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Autores principales:	Stephen R. Adams, Howard C. Yang, Elamprakash N. Savariar, Joe Aguilera, Jessica L. Crisp, Karra A. Jones, Michael A. Whitney, Scott M. Lippman, Ezra E. W. Cohen, Roger Y. Tsien, Sunil J. Advani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/68ca94c8c46f45f584cf14bf29ee56ae
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spelling	oai:doaj.org-article:68ca94c8c46f45f584cf14bf29ee56ae2021-12-02T14:40:14ZAnti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize10.1038/ncomms130192041-1723https://doaj.org/article/68ca94c8c46f45f584cf14bf29ee56ae2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13019https://doaj.org/toc/2041-1723Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death due to ionizing radiation.Stephen R. AdamsHoward C. YangElamprakash N. SavariarJoe AguileraJessica L. CrispKarra A. JonesMichael A. WhitneyScott M. LippmanEzra E. W. CohenRoger Y. TsienSunil J. AdvaniNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen R. Adams Howard C. Yang Elamprakash N. Savariar Joe Aguilera Jessica L. Crisp Karra A. Jones Michael A. Whitney Scott M. Lippman Ezra E. W. Cohen Roger Y. Tsien Sunil J. Advani Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
description	Drugs that sensitize tumour cells to ionizing radiation are prized because they can overcome resistance to radiotherapy. Here, the authors show that anti-tubulin drugs conjugated to cetuximab or trastuzumab can radiosensitize EGFR- or HER2-expressing tumors by increasing DNA damage and cell death due to ionizing radiation.
format	article
author	Stephen R. Adams Howard C. Yang Elamprakash N. Savariar Joe Aguilera Jessica L. Crisp Karra A. Jones Michael A. Whitney Scott M. Lippman Ezra E. W. Cohen Roger Y. Tsien Sunil J. Advani
author_facet	Stephen R. Adams Howard C. Yang Elamprakash N. Savariar Joe Aguilera Jessica L. Crisp Karra A. Jones Michael A. Whitney Scott M. Lippman Ezra E. W. Cohen Roger Y. Tsien Sunil J. Advani
author_sort	Stephen R. Adams
title	Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
title_short	Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
title_full	Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
title_fullStr	Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
title_full_unstemmed	Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize
title_sort	anti-tubulin drugs conjugated to anti-erbb antibodies selectively radiosensitize
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/68ca94c8c46f45f584cf14bf29ee56ae
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Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize

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