SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase

Summary: Legionella pneumophila grows intracellularly within a replication vacuole via action of Icm/Dot-secreted proteins. One such protein, SdhA, maintains the integrity of the vacuolar membrane, thereby preventing cytoplasmic degradation of bacteria. We show here that SdhA binds and blocks the ac...

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Autores principales: Won Young Choi, Seongok Kim, Philipp Aurass, Wenwen Huo, Elizabeth A. Creasey, Marc Edwards, Martin Lowe, Ralph R. Isberg
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/68d2299132fb4f0b9cf551af7808893d
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