GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application

Abstract In periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester—poly (butylene succinate...

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Autores principales:	Seyedramin Pajoumshariati, Hadi Shirali, Seyedeh Kimia Yavari, Sogol Naghavi Sheikholeslami, Ghogha Lotfi, Fatemeh Mashhadi Abbas, Alireza Abbaspourrad
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/68d6059a409443be8f4a28892b30dc5e
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spelling	oai:doaj.org-article:68d6059a409443be8f4a28892b30dc5e2021-12-02T12:32:10ZGBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application10.1038/s41598-018-25952-12045-2322https://doaj.org/article/68d6059a409443be8f4a28892b30dc5e2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25952-1https://doaj.org/toc/2045-2322Abstract In periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester—poly (butylene succinate-co-glycolate) (PBSGL), and fabricate a PBSGL membrane by electrospinning. We then aimed to evaluate the in vitro effect of the glycolate ratio on the biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs), and evaluate in vivo bone regeneration using these membranes in rabbit calvarial defects by histology. Increasing the glycolate ratio of electrospun PBSGL membranes resulted in better cell attachment, greater cell metabolic activity, and enhanced osteogenic potential at both transcriptional and translational levels. Histologic and histomorphometric evaluations revealed further that bone defects covered with fibers of higher glycolate ratios showed more bone formation, with no adverse inflammatory response. These results suggest that novel PBSGL electrospun nanofibers show great promise as GBR membranes for bone regeneration.Seyedramin PajoumshariatiHadi ShiraliSeyedeh Kimia YavariSogol Naghavi SheikholeslamiGhogha LotfiFatemeh Mashhadi AbbasAlireza AbbaspourradNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seyedramin Pajoumshariati Hadi Shirali Seyedeh Kimia Yavari Sogol Naghavi Sheikholeslami Ghogha Lotfi Fatemeh Mashhadi Abbas Alireza Abbaspourrad GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
description	Abstract In periodontics, osteoconductive biodegradable guided bone regeneration (GBR) membranes with acceptable physico-mechanical properties are required to fix alveolar bone defects. The objectives of the present study were to produce and characterize a novel co-polyester—poly (butylene succinate-co-glycolate) (PBSGL), and fabricate a PBSGL membrane by electrospinning. We then aimed to evaluate the in vitro effect of the glycolate ratio on the biocompatibility and osteogenic differentiation of mesenchymal stem cells (MSCs), and evaluate in vivo bone regeneration using these membranes in rabbit calvarial defects by histology. Increasing the glycolate ratio of electrospun PBSGL membranes resulted in better cell attachment, greater cell metabolic activity, and enhanced osteogenic potential at both transcriptional and translational levels. Histologic and histomorphometric evaluations revealed further that bone defects covered with fibers of higher glycolate ratios showed more bone formation, with no adverse inflammatory response. These results suggest that novel PBSGL electrospun nanofibers show great promise as GBR membranes for bone regeneration.
format	article
author	Seyedramin Pajoumshariati Hadi Shirali Seyedeh Kimia Yavari Sogol Naghavi Sheikholeslami Ghogha Lotfi Fatemeh Mashhadi Abbas Alireza Abbaspourrad
author_facet	Seyedramin Pajoumshariati Hadi Shirali Seyedeh Kimia Yavari Sogol Naghavi Sheikholeslami Ghogha Lotfi Fatemeh Mashhadi Abbas Alireza Abbaspourrad
author_sort	Seyedramin Pajoumshariati
title	GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
title_short	GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
title_full	GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
title_fullStr	GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
title_full_unstemmed	GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
title_sort	gbr membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/68d6059a409443be8f4a28892b30dc5e
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GBR membrane of novel poly (butylene succinate-co-glycolate) co-polyester co-polymer for periodontal application

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