Promoter-enhancer interactions identified from Hi-C data using probabilistic models and hierarchical topological domains

Proximity-ligation methods like Hi-C map DNA-DNA interactions and reveal its organization into topologically associating domains (TADs). Here the authors describe PSYCHIC, a computational approach for analysing Hi-C data that allows the identification of promoter-enhancer interactions.

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Auteurs principaux: Gil Ron, Yuval Globerson, Dror Moran, Tommy Kaplan
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/68db1c1c65d14e61bd6b9fb135f785e7
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