Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in tumor tissue, and identify a proliferative CD8 + T-c...

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Autores principales:	Nicholas Borcherding, Ajaykumar Vishwakarma, Andrew P. Voigt, Andrew Bellizzi, Jacob Kaplan, Kenneth Nepple, Aliasger K. Salem, Russell W. Jenkins, Yousef Zakharia, Weizhou Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/69009c376bfa4f7e91c1b591b507d8ed
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spelling	oai:doaj.org-article:69009c376bfa4f7e91c1b591b507d8ed2021-12-02T13:23:49ZMapping the immune environment in clear cell renal carcinoma by single-cell genomics10.1038/s42003-020-01625-62399-3642https://doaj.org/article/69009c376bfa4f7e91c1b591b507d8ed2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01625-6https://doaj.org/toc/2399-3642Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in tumor tissue, and identify a proliferative CD8 + T-cell population, which may be relevant for anti-cancer responses.Nicholas BorcherdingAjaykumar VishwakarmaAndrew P. VoigtAndrew BellizziJacob KaplanKenneth NeppleAliasger K. SalemRussell W. JenkinsYousef ZakhariaWeizhou ZhangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Nicholas Borcherding Ajaykumar Vishwakarma Andrew P. Voigt Andrew Bellizzi Jacob Kaplan Kenneth Nepple Aliasger K. Salem Russell W. Jenkins Yousef Zakharia Weizhou Zhang Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
description	Borcherding and Vishwakarma et al. characterize the tumor immune microenvironment in treatment-naïve clear cell renal carcinoma patients using single-cell RNA- and T-cell receptor sequencing. They find CD8 + T cells and macrophages are enriched in tumor tissue, and identify a proliferative CD8 + T-cell population, which may be relevant for anti-cancer responses.
format	article
author	Nicholas Borcherding Ajaykumar Vishwakarma Andrew P. Voigt Andrew Bellizzi Jacob Kaplan Kenneth Nepple Aliasger K. Salem Russell W. Jenkins Yousef Zakharia Weizhou Zhang
author_facet	Nicholas Borcherding Ajaykumar Vishwakarma Andrew P. Voigt Andrew Bellizzi Jacob Kaplan Kenneth Nepple Aliasger K. Salem Russell W. Jenkins Yousef Zakharia Weizhou Zhang
author_sort	Nicholas Borcherding
title	Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
title_short	Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
title_full	Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
title_fullStr	Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
title_full_unstemmed	Mapping the immune environment in clear cell renal carcinoma by single-cell genomics
title_sort	mapping the immune environment in clear cell renal carcinoma by single-cell genomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/69009c376bfa4f7e91c1b591b507d8ed
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Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

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