Strength of immune selection in tumors varies with sex and age

Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint bloc...

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Autores principales: Andrea Castro, Rachel Marty Pyke, Xinlian Zhang, Wesley Kurt Thompson, Chi-Ping Day, Ludmil B. Alexandrov, Maurizio Zanetti, Hannah Carter
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/693e54a260044a968cb8e417f4b862c9
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