Strength of immune selection in tumors varies with sex and age

Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint bloc...

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Autores principales:	Andrea Castro, Rachel Marty Pyke, Xinlian Zhang, Wesley Kurt Thompson, Chi-Ping Day, Ludmil B. Alexandrov, Maurizio Zanetti, Hannah Carter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/693e54a260044a968cb8e417f4b862c9
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spelling	oai:doaj.org-article:693e54a260044a968cb8e417f4b862c92021-12-02T16:45:30ZStrength of immune selection in tumors varies with sex and age10.1038/s41467-020-17981-02041-1723https://doaj.org/article/693e54a260044a968cb8e417f4b862c92020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17981-0https://doaj.org/toc/2041-1723Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint blockade therapies.Andrea CastroRachel Marty PykeXinlian ZhangWesley Kurt ThompsonChi-Ping DayLudmil B. AlexandrovMaurizio ZanettiHannah CarterNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrea Castro Rachel Marty Pyke Xinlian Zhang Wesley Kurt Thompson Chi-Ping Day Ludmil B. Alexandrov Maurizio Zanetti Hannah Carter Strength of immune selection in tumors varies with sex and age
description	Here the authors show that stronger immune selection and immune editing in females and younger patients lead to the accumulation of poorly presented driver mutations in tumors. These results may explain why young and female patients are characterized by lower response rates to immune checkpoint blockade therapies.
format	article
author	Andrea Castro Rachel Marty Pyke Xinlian Zhang Wesley Kurt Thompson Chi-Ping Day Ludmil B. Alexandrov Maurizio Zanetti Hannah Carter
author_facet	Andrea Castro Rachel Marty Pyke Xinlian Zhang Wesley Kurt Thompson Chi-Ping Day Ludmil B. Alexandrov Maurizio Zanetti Hannah Carter
author_sort	Andrea Castro
title	Strength of immune selection in tumors varies with sex and age
title_short	Strength of immune selection in tumors varies with sex and age
title_full	Strength of immune selection in tumors varies with sex and age
title_fullStr	Strength of immune selection in tumors varies with sex and age
title_full_unstemmed	Strength of immune selection in tumors varies with sex and age
title_sort	strength of immune selection in tumors varies with sex and age
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/693e54a260044a968cb8e417f4b862c9
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Strength of immune selection in tumors varies with sex and age

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