Generation of humoral immune responses to multi-allele PfAMA1 vaccines; effect of adjuvant and number of component alleles on the breadth of response.

There is increasing interest in multi-allele vaccines to overcome strain-specificity against polymorphic vaccine targets such as Apical Membrane Antigen 1 (AMA1). These have been shown to induce broad inhibitory antibodies in vitro and formed the basis for the design of three Diversity-Covering (DiC...

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Autores principales: Kwadwo A Kusi, Bart W Faber, Vanessa Riasat, Alan W Thomas, Clemens H M Kocken, Edmond J Remarque
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2010
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Acceso en línea:https://doaj.org/article/69a2b7ef494846f1ac5ad15f4aa463a8
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