GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

GATA3 induces human T-cell commitment by restraining Notch activity and repressing NK-cell fate

Strong Notch signalling promotes initial T cell lineage specification of lymphoid progenitors but is also permissive for thymic natural killer (NK) cell development. Here the authors show that GATA3 directs human T-lineage commitment by modulating Notch activity and repressing the NK programme.

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Inge Van de Walle, Anne-Catherine Dolens, Kaat Durinck, Katrien De Mulder, Wouter Van Loocke, Sagar Damle, Els Waegemans, Jelle De Medts, Imke Velghe, Magda De Smedt, Bart Vandekerckhove, Tessa Kerre, Jean Plum, Georges Leclercq, Ellen V. Rothenberg, Pieter Van Vlierberghe, Frank Speleman, Tom Taghon
Format: article
Langue:EN
Publié: Nature Portfolio 2016
Sujets:
Science
Q
Accès en ligne:https://doaj.org/article/69f154ad67fa47219da5b76adf207d5e
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires

Documents similaires