Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progressio...

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Autores principales:	Marco Bolis, Daniela Bossi, Arianna Vallerga, Valentina Ceserani, Manuela Cavalli, Daniela Impellizzieri, Laura Di Rito, Eugenio Zoni, Simone Mosole, Angela Rita Elia, Andrea Rinaldi, Ricardo Pereira Mestre, Eugenia D’Antonio, Matteo Ferrari, Flavio Stoffel, Fernando Jermini, Silke Gillessen, Lukas Bubendorf, Peter Schraml, Arianna Calcinotto, Eva Corey, Holger Moch, Martin Spahn, George Thalmann, Marianna Kruithof-de Julio, Mark A. Rubin, Jean-Philippe P. Theurillat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3
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spelling	oai:doaj.org-article:6a080edb8c7340f18674ce8c5a8eaff32021-12-05T12:22:20ZDynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression10.1038/s41467-021-26840-52041-1723https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff32021-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26840-5https://doaj.org/toc/2041-1723Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progression.Marco BolisDaniela BossiArianna VallergaValentina CeseraniManuela CavalliDaniela ImpellizzieriLaura Di RitoEugenio ZoniSimone MosoleAngela Rita EliaAndrea RinaldiRicardo Pereira MestreEugenia D’AntonioMatteo FerrariFlavio StoffelFernando JerminiSilke GillessenLukas BubendorfPeter SchramlArianna CalcinottoEva CoreyHolger MochMartin SpahnGeorge ThalmannMarianna Kruithof-de JulioMark A. RubinJean-Philippe P. TheurillatNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marco Bolis Daniela Bossi Arianna Vallerga Valentina Ceserani Manuela Cavalli Daniela Impellizzieri Laura Di Rito Eugenio Zoni Simone Mosole Angela Rita Elia Andrea Rinaldi Ricardo Pereira Mestre Eugenia D’Antonio Matteo Ferrari Flavio Stoffel Fernando Jermini Silke Gillessen Lukas Bubendorf Peter Schraml Arianna Calcinotto Eva Corey Holger Moch Martin Spahn George Thalmann Marianna Kruithof-de Julio Mark A. Rubin Jean-Philippe P. Theurillat Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
description	Transcriptional changes during prostate cancer progression are not yet fully understood. Here, the authors integrate a transcriptomics atlas of prostate cancer and validate it with preclinical models and single-cell RNA-seq, revealing the role of EZH2 and macrophage polarisation in tumour progression.
format	article
author	Marco Bolis Daniela Bossi Arianna Vallerga Valentina Ceserani Manuela Cavalli Daniela Impellizzieri Laura Di Rito Eugenio Zoni Simone Mosole Angela Rita Elia Andrea Rinaldi Ricardo Pereira Mestre Eugenia D’Antonio Matteo Ferrari Flavio Stoffel Fernando Jermini Silke Gillessen Lukas Bubendorf Peter Schraml Arianna Calcinotto Eva Corey Holger Moch Martin Spahn George Thalmann Marianna Kruithof-de Julio Mark A. Rubin Jean-Philippe P. Theurillat
author_facet	Marco Bolis Daniela Bossi Arianna Vallerga Valentina Ceserani Manuela Cavalli Daniela Impellizzieri Laura Di Rito Eugenio Zoni Simone Mosole Angela Rita Elia Andrea Rinaldi Ricardo Pereira Mestre Eugenia D’Antonio Matteo Ferrari Flavio Stoffel Fernando Jermini Silke Gillessen Lukas Bubendorf Peter Schraml Arianna Calcinotto Eva Corey Holger Moch Martin Spahn George Thalmann Marianna Kruithof-de Julio Mark A. Rubin Jean-Philippe P. Theurillat
author_sort	Marco Bolis
title	Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
title_short	Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
title_full	Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
title_fullStr	Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
title_full_unstemmed	Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
title_sort	dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6a080edb8c7340f18674ce8c5a8eaff3
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Dynamic prostate cancer transcriptome analysis delineates the trajectory to disease progression

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