Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9

Abstract Complete removal of hepatitis B virus (HBV) DNA from nuclei is difficult by the current therapies. Recent reports have shown that a novel genome-editing tool using Cas9 with a single-guide RNA (sgRNA) system can cleave the HBV genome in vitro and in vivo. However, induction of a double-stra...

Full description

Saved in:
Bibliographic Details
Main Authors: Takeshi Kurihara, Takasuke Fukuhara, Chikako Ono, Satomi Yamamoto, Kentaro Uemura, Toru Okamoto, Masaya Sugiyama, Daisuke Motooka, Shota Nakamura, Masato Ikawa, Masashi Mizokami, Yoshihiko Maehara, Yoshiharu Matsuura
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/6a0a9b8099f94b9897ea32cd37e0cdaf
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/6a0a9b8099f94b9897ea32cd37e0cdaf

Similar Items