Virulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses

Abstract Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context of different IAV subtypes in mice. Here, we demonstrate that, as with the previously...

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Autores principales: Irina V. Alymova, Jonathan A. McCullers, Ram P. Kamal, Peter Vogel, Amanda M. Green, Shane Gansebom, Ian A. York
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/6a2f72fbdaf049d9848583d8069f3f83
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