A modular self-adjuvanting cancer vaccine combined with an oncolytic vaccine induces potent antitumor immunity
Successful cancer immune therapy correlates with a T cell-inflamed tumour microenvironment. Authors show here that co-administration of a self-adjuvanting protein vaccine and an antigen-expressing oncolytic virus in an optimised regimen strongly enhances T cell immunogenicity and may turn non-inflam...
Enregistré dans:
Auteurs principaux: | Krishna Das, Elodie Belnoue, Matteo Rossi, Tamara Hofer, Sarah Danklmaier, Tobias Nolden, Liesa-Marie Schreiber, Katharina Angerer, Janine Kimpel, Sandra Hoegler, Bart Spiesschaert, Lukas Kenner, Dorothee von Laer, Knut Elbers, Madiha Derouazi, Guido Wollmann |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/6a4885a11bbe41c6aef5c595a4d1525a |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Adjuvant oncolytic virotherapy for personalized anti-cancer vaccination
par: D. G. Roy, et autres
Publié: (2021) -
Chemogenetic ON and OFF switches for RNA virus replication
par: E. Heilmann, et autres
Publié: (2021) -
Heparan sulfate proteoglycans serve as alternative receptors for low affinity LCMV variants.
par: André Volland, et autres
Publié: (2021) -
SELECTED ASPECTS OF ALLO- AND XENOGRAFT MODEL APPLICATIONS FOR DEVELOPING NOVEL ANTI-CANCER VACCINES AND ONCOLYTIC VIRUSES
par: T. S. Nepomnyashchikh, et autres
Publié: (2019) -
Mechanisms that allow vaccination against an oncolytic vesicular stomatitis virus-encoded transgene to enhance safety without abrogating oncolysis
par: Amanda W. K. AuYeung, et autres
Publié: (2021)